So sorry you want to help us so in this session we asked for some submission of cases so we're
going to have someone come up and present a case and then we're just going to do a little
chitty chat right Paul talk through a case that's it yeah I'm between evident
Castello I think you need to move no no you're staying there I don't want to sit
next to him hello hi my name is dr. the chef's key I'm from New York and I'm
psychiatrist okay okay dr. the chef's key from New York and my specialty is
psychiatry we see different type of patients in our office offices in
Manhattan young people middle-aged people different pathologies
psychopatology and lately we start notice that we see many people with some
symptoms of long COVID of course already we educated about long COVID and we
start to see them and help him as much as we can I want to present one of my
patient she's 65 years old white female she's professor in pharmacology she
currently work as a scientist in some of cosmetic field she was very very high
function in person in her professional life in her social life until the
pandemic the comorbidity very you know very mild mild hypertension no
mitigation osteoarthritis fibromyalgia question mark remote history of
Stobak ulcer depression depression she was is depressed patient of mine for
10 years so she came to me about 10 years ago when she lost her husband and she
was severely depressed grieving and it was very complicated case but she got
better and she was doing very well no history surgery or hospitalization she
started to feel unwell in few weeks after the second vaccination of Pfizer
vaccine both vaccine was Pfizer in February 21 she started to feel dizzy at
time and very unusual very very strange headache which she never experienced
before resemble migraine headache later she developed disney a shortness of
breath then frequent fatigue intolerance to exercise tachycardia blood
pressure ability chest pain at time and she started seeing she started feeling
sorry more depressed at that time of course just wondering what's going on
with with myself she started to see different different specialist she was
very upset very depressed and used to say someone kidnapped my life at this
point okay okay she said to see different specialist starting from primary
medical doctor blood test increase LDL a little bit high antibody IgG MRI of the
brain no abnormality IgG normal echocardia no abnormality endoscopy she saw GI
doctor who took five biopsy no abnormalities pulmonary function test
pulmonologist and of course every every doctor just took care of something
actually neurologist first neurologist she saw she proposed buttocks injection
and she was taking this buttocks injection every three months it was
helpful she said it was very helpful headache is subside another neurologist
was dr. Benjamin Natal son Natal son maybe you know this name he is
professor professor from Mount Sinai Hospital started her own Madafino it's
provigil 200 milligram she she said she was taking just hundred milligram of
provigil and on PRN basis when she need more mental activity work on the
computer social interaction etc. psychiatrist myself when she became more
depressed having all this problem you know like all psychiatrists I increase
her medications I increase her Simbalta at this point she was on Simbalta 40 and
doing fine we went to 60 milligram and continue to take Zalpidem
unfortunately Zalpidem it's only medication which make help her with sleep
and clonazoparm small dose point five PRN for anxiety we try and successfully
other sleeping arrangement but it was unfortunately no cure it was trusadone
doxypine zyprexa valerian roots etc. gastroenterologist after after the the
evaluation said we we did not find anything no ulcer and started her own
format format didn't 20 milligram for three weeks it did not help and she she
start to use holistic supplement it's called God a life it's some something
from Japanese scientist was developed but here in the United States it's help
a lot and then that's basically about doctors and she is being a pharmacologist
professor in pharmacology she was of course going to websites and talk to
different you know provider people not exactly the one but different one and
this is her supplement what she was taken it was knock but regular knock not
this Italian knock resveratrol serozyme through Niger 300 milligram magnesium
high dosage I believe vitamin D3 say zinc prebiotics I believe that one just
regular in from the pharmacy and probiotic from tundrax for my point is
well she she she lost she lost from the beginning she claimed she lost 80% of
her capacity functional capacity she was she was working only part time very
part time only from home talking to phone to college trying to do some test
trying to write paper papers and was very difficult at this point of time just
lately I spoke with her a couple days ago she she's doing okay she's doing much
better but she said I'm still like thinking like you know functioning on my
40% capacity and still thinking she lost 60% what I have to say she was
tremendously distraught she was she was in such a condition it's you know it's
psychiatry you know it's a depression but she experienced anger outburst she
experienced frustration she she was like was very very very frustrated I even
like comparing is this like some stage of you know when you when you have
incurable disease if you remember Swiss psychiatrist Elizabeth Elizabeth Kerber
Ross developed few study of the this anger buggy depression and acceptance and
basically what I say she's an acceptance now and she is like doing what she needs
to do and actively actively searching for any treatment questions just to
summarize currently the patient reports that she's functioning at what percentage
of her normal baseline right now she's functioning but 40% 40% yeah that's
quite low her chief complaint in terms of symptoms right now is it mostly anxiety
frustration or is it the other physiological depression is gone she's
tired fatigue brain fog she can work in the computer a long time
autonomic instability you can come and sit there's a microphone there we can have
a chat so dysautonomia sure so so classic long-covid long-vax mecfs I just
want to point out in the presentation so if you if you read about papers on a
mecfs which is what long-covid long-vax is I mean the classic descriptions
historically over decades right is immense amount of testing returning
normal physicians don't know what to do because they can't find anything
actionable on the test and then numerous numerous specialists so this is quite a
classic case of a presentation of long-covid so okay she's a 40% geez
Scott so peer I mean the common denominator and I think Joel maybe has
spoken about it in his lecture is brain fog fatigue post exertional post exertional
malaise headaches I mean those are the classic features and disautonomia is the
second side menu so I mean there's no simple answer and you know you have to
try sequentially different things so just you know just one or two things I mean
hyperbaric oxygen we know in randomized controlled trials works and so but what
do you what happened with the five sessions no response at all this you
didn't feel any different yes she said no the microphone she said not really yeah
so the question is yes so the question is how many sessions does a patient need
before you can say they fail because that's important because we've had
patients before who don't respond yeah so that's the answer so she may have
quit too soon which which well I I've heard I definitely I think Scott you've
had experiences where the benefits were only realized after numerous sessions I
will tell you one of the experts in the field has told me that in his
experience generally by 10 if you don't get one you're not gonna see one but I
think that has not been true in some cases Scott yeah and a lot of people are
using soft shell as opposed to hard shell and with soft shell you're less
likely to get a reperfusion inflammatory response but it's also
probably gonna take more sessions to determine whether or not you know and
that fascinating thing about hyperbaric oxygen is as intensive as I thought it
was the oxygen it's not the oxygen it's the pressure and the pressure has this
remarkable anti-inflammatory things so if we think of this as an inflammatory
disease that this is an anti-inflammatory therapy and you need you know repeated
episodes obviously it's expensive and resource intensive so you have to if it's
not working you have to quit there's one other issue I have with hyperbaric not
I have an issue with her barric but in the other expert has agreed that it's not
a first-line therapy that's I would not send someone hyperbaric up front like
the way I see this case just as people who have created and worked largely
around the eye recover protocol again we all do different things but they
haven't gotten you know standard first and second-line therapies even for mass
cell ivermectin LDN and we can talk about that what we would do if we saw the
patient but I wouldn't have started with hyperbaric now I know have I have some
colleagues who they just they hit everyone with hyperbaric straight off I
think that they should get treatment first she actually took it just lately
not long time ago after the all the supplement it was like last last
treatment so what what what what I would say about this is when I meet with
patients for the first time I'm looking at the roadblocks we need to get out of
the way to even get them to the starting line and she's on a statin right so if
she's having fatigue we can say the statin is is undermining her mitochondrial
function and and we can also say that it's inhibiting her body's own production
of endogenous steroids to decrease inflammation and it's and it's also
undermining her body's ability to make her her own hormones right the statin
is absolutely not needed right and and she has some of the classic initial
science of microclotting and replacing the statin with natokinase bringing it
in over time you're probably gonna get rid of the topral the loosartan and the
statin in one fell swoop so you know it just as a general point there's a really
good randomized controlled trial comparing natokinase this is that stuff in
terms of athlete atherosclerosis reversal the statin caused atherosclerosis
progression the gold standard used by these so-called heart doctors whereas
the natokinase in a randomized double-blind placebo controlled trial
caused a reversion of regression of the atherosclerosis it's truly astonishing
so these stats so the commonest drug sold in this country the commonest drug
in this country is a torvastatin and it's a poisonous drug and it's completely
useless so but Paul let's just I think we need to be consistent cancer Paul so
cancers the only drug that it works on isn't that interesting for coronary
diseases useless it's good for cancer because cancer cells turn over they
need cholesterol for cell membrane so for cancer it's good for the heart it's
bad good point clip here so I would agree natokinase would be something that you
would want to do aspirin maybe the other thing was magnesium so you know Dr.
Guster talks about this and the type of magnesium is really important magnesium
oxide or is he completely useless it's often you know hyperabsorbable magnesium
the absorption is like 3% so giving you know magnesium generally is wasted time
you must give the the 3nH is the one which penetrates best into the cns so
it actually makes a difference should we just maybe I don't know where are we
with time for me can I ask a question like have you thought about embarking on
some of our first-line therapies for you know in I recover things like which are
multi-mechanistic have a pretty high incidence of positive response but I
would for instance if I saw that patient I would do some of the changes they
just mentioned but I mean at the risk of sounding simplistic I've remarked in
step one absolutely in fact I would have started with that that was my point
about and this is criticism yes and that's what we're here to learn right
I just all know from your history so I mean other make them it is not a horse
dewormer it should be used by psychiatrists it should be used by
cardiologists it should be used by gynecologists it should be used by all
doctors because it is a I mean so and it's a remarkable thing that I say such
a thing because it used to be just a horse dewormer but it's it's such a
remarkable drug it's I mean it sounds some completely simplistic but you name
it it does it and you know what I like about peer I mean not everything is he
divides his patients into two groups other vector other Mekton responders and
other Mekton non-responders and it's it's a way of classifying them and those
that respond do well those that don't you know you in trouble yeah it's I find
it's somewhat prognostic actually like Paul just said when they don't respond
I've remarked and it's not doesn't mean I can't help them and find other things
it's just been my experience that the road ahead is going to be longer and
steeper it's just it seems somehow harder to help them but the beauty is
when you get someone especially for the therapeutic relationship you start them
on a medicine which suddenly they feel a palpable difference in their
functioning and how they feel you know there you can really build on with them
and help them more that's my point I think psychiatry psychiatry should be
very involved and those patients need psychological help a lot yeah and it's
a multi-system disease I mean you know the average number of symptoms of a
vaccine injured is 23 and so obviously you know a patient goes to a physician has
this list of symptoms they say this is a functional disease just because there's
no disease that causes this but there's a disease it's called spike protein the
so I would just literally on this case I think it's an illustrative case that a
practitioner let's say you don't have experience treating these kind of
patients with all of these symptoms especially that triad of the brain fog
fatigue and post-mortem exertion malaise but I would literally start just by the
book follow kind of the first line therapies and you know we talked about
some of the updates you know we have some trials evidence to support we have L
arginine and vitamin C in there there's a good trial showing the benefits of
that and so kind of the simple stuff that we have on our first line and you know
just that the risk of sounding simplistic I would start that then I would
focus on MCAS and then you have to address the microcladding at some point
and so there are definitely some things that you could take this patient through
and I think you'll you'll see some benefits yeah thank you
wow it's a lot different up here how many people feel like they've been on a
roller coaster but it's been a good one and I just I'm gonna steal a minute for
my thing and then I'll talk like an auctioneer I was just reading last week
about having joy and suffering and I'm like oh god that's not me anybody else
not have joy and suffering but what it said was have joy and suffering for the
right things because that produces perseverance perseverance produces
character and character produces hope and that is what we see here that's what
these people have done that's what you have done that's what we're trying to do
we have hope because I look around and I feel like I'm alone because I'm in from
Utah and there's not very many of us and but I have hope because I have hope
because I'm persevered and I've suffered and we are gonna win I have hope for the
future of medicine for the future of honest medicine so thank you for letting
me thank you say that thank you guys for for providing us an opportunity to have
courage and to stand up thank you okay today we're gonna talk about a 59 year
old white male six foot four inch I'm sorry six foot four inches tall sorry
six foot four he's I would say he's more pretty significantly deconditioned at
this time he lives at 5,000 feet of elevation has done so for many years
he's an accountant by trade he's married for 35 years has two adult children who
do not live with him and a dog and six chickens he lives in a suburban home
past medical history is pretty insignificant he up until recently did
not take any medications he has a history of some orthopedic surgeries knee
replacement hip replacement and then also he had an appendectomy all without
any ensuing problems there was only one note in his past medical history that
was somewhat significant don't know if it's clinically relevant relevant in
2010 he had the H1N1 virus the swine flu he was pretty sick for about a week
with high fevers he then developed tinnitus which lasted for almost two
years has since resolved itself and then also had developed peripheral
neuropathy which has continues to this day although not as severe in 2016 his
wife who's a medical provider had a pretty significant concerns about this
ongoing peripheral neuropathy had a very thorough work up with scans and EMGs and
was determined that it was idiopathic and there was nothing they could do didn't
have diabetes or any other circulatory or muscle problems that they could find in
August of 2021 this gentleman contracted COVID during a week long bicycle ride
across Iowa he was riding with his wife and some friends and about five days
into the seven day ride he got ill they did have ivermectin he was treated
immediately but continued the ride he wasn't that sick after finishing the
ride his wife who was with him also contracted COVID they returned back to
their home in Salt Lake she recovered pretty quickly he seemed to be taking a
little bit more time to recover and so he was seen in an urgent care he was
given five days of oral prednisone went home that was not the request of his
wife she thought that might be a good idea they didn't really want to do that
but anyway he went home and then a few days later he was still not doing great
so he went and had the monoclonal antibody infusion after which he stated
he felt like he was getting better fast forward now this case I will say
initially was not thought of as a long COVID because of the length of time in
presentation in January of 2023 this patient and his wife she had was not
working in the system anymore and they only had catastrophic insurance so she
ran some basic labs just to make sure that he was doing you know that they
were doing okay or in labs on both of them notice that his hemoglobin and
hematocrit were significantly elevated with a hematocrit of about 60 and a
hemoglobin of about 20 to 20 or 22 she immediately placed him on aspirin and
natokinase some seropeptase some lumbo kinase they were on alternating days the
patient seemed to be doing the same he's a very doesn't complain about anything
he's an accountant so he sits all day didn't really complain she also
recommended donating blood and so he did and felt worse fast forward to June he
had been he had been on a trip to Florida he rode a bike couldn't ride more than
two blocks she became more concerned when they returned home the patient she
gave him a pulse oximeter he went to walk the dog and when he came back he
said that he had oxygen drops into the high 70s and when he was standing they
could not get his oxygen saturations above 85 she became severe pretty
significantly alarmed at which time she took him to the emergency room now I
can't talk like an auctioneer so I'm gonna say please look at these and read
these I will talk about the significant ones or the ones that that that were
positive the patient had an extensive workup over the next up until just so
over like a six to seven month period it she was concerned about a clot there
was no clot found his EKG was normal he had two echoes insignificant this is
multiple visits he was supposed to be admitted to the hospital but refused
they were not actually treating very well they sent him home on oxygen which he
did intermittently because he's like well I don't feel that bad so he had a VQ
scan he had high-resolution CTPA which was the first thing other than the
pulmonary function test I'm sorry he did have pulmonary function tests done his
DLCO was at 40% he needed six liters of oxygen to walk across the floor down a
hallway to keep his oxygen saturations above 90% on the high-resolution CT he
had an enlarged right enlarged main pulmonary artery and some what they
described as mild mosaic in on expiration had a heart cath done with the
pulmonary hypertension specialist and was diagnosed with pre-capillary pulmonary
hypertension along with the low normal COCl on the right of your screen you'll
see a whole bunch of other labs that the wife had done because they were listed
on the FLCCC website he also had a workup done because of the elevated
hemoglobin and hematocrit which was for polycythemia which was not found to be a
concern at the time treatment we've kind of discussed that along the way just a
few additions he was on I would say pretty much the protocols for the
supplements and everything he had been on that prior when he came down with
COVID with the addition of a few things TA1 which they talked about earlier in
the conference it's a peptide for helping immune system he was also placed by
his wife on John Luton and tax arrest which are two bioregulator peptides that
was a two-month course to see if that would help his lungs when they first
thought maybe it was a long problem perhaps a slight increase in his pulmonary
function testing unsure if that's clinically relevant sorry after the
pulmonary hypertension diagnosis he was placed on sildenafil at 20 milligrams
three times a day and his wife placed him on metformin also 500 milligrams
BID in January of this year the patient wife had done some more research he was
placed on venipept which is a bioregulator along with all of the
other things that he's still on and I will say that I talked to this gentleman
last night and in the last five days he has had significant improvements which
I'm not exactly sure what the cause is whether it's this bioregulator it's a
two-month course he his oxygen saturations at night would normally drop
into the 70s and he's now over 85 to 88 and into the 90s for the vast
majority of the night he says he has some more energy he's able to walk a
little bit further you know without needing extra oxygen or anything so that
that's his current status and there's a lot other things involved like he had
sleep studies and all of that done with no significant findings can you go back
a slide I think I know only because I love the picture so much I think the
picture is the answer maybe I'll just start with my first thoughts and then
Scott tell me what you would do here but I mean the way I see this case right
and not only as a vaccine injury I can't call myself an expert because I'll
never be one but but as a pulmonologist I mean this is slammed up as a gas
exchange problem period right so there's unexplained hypoxemia so I didn't
say it was on the screen though he's not faxed no that's a bit long COVID long
back good I'm sorry and I did notice that so this is a long COVID patient who
suddenly has presumably did not used to have I mean he did a 400-mile bike ride
before he got sick yeah yeah so I can't imagine a gas exchange problem then but
there's clearly not some problem that's causing an uptake deficit and uptake of
oxygen and so they ruled out the big stuff right CTPA there's no large
inclusive thrombus anywhere they find some mild pre-capillary hypertension that
that would not be enough to explain that kind of hypoxemia right so there's no
there's a sort of this mystery hypoxemia well it was brought up multiple
times like what about micro clotting that's where we're heading that's actually
why we chose this case because I thought this was a really kind of illustrative
case of what I think is going on there's microclinic and if you look at that
picture right you see this picture it's got like spike protein you know but you
see this aggregation of red cells right and so as the cells are suspended in the
blood they're supposed to be excuse me Paul I'm demonstrating how cells
suspended in fluid should be colloidally suspended which are separate from each
other so the surface area of the cell can participate in gas exchange across the
capillary membrane as they clump together if you look you see all those
cells inside they cannot participate in gas exchange right they're not in
contact with the capillary no gases can diffuse back and forth the carbon dioxide
oxygen so I think this is really illustrative of significant blood
clumping right so that's one thing right it's one end of here I guess I'm done
Paul you go and you know it's really hard for me to agree with you so I mean
when you have a problem of oxygen utilization you want to know is this a
mitochondrial problem and you know because which is a big issue that you
can't actually utilize oxygen or is this an oxygenation problem clearly this is
an oxygenation problem clearly they're not macroclots so you have microclotting
and red blood cell clumping and we spoke about the clumping which is really
interesting Paul is there anything that breaks like it's like a CD147 CD147 and
then it causes the clumping is there anything that blocks that receptor do
you know I was just thinking it would be really great to give them some there was
there was a drug I don't know it I have heard about it that prevents red cell
clot are we talking about ivermectin again again yes is that all we do is we
just talk about ivermectin so to encourage you this patient was also
placed on a three-week course of ivermectin he was in after we met with
you in the fall this fall which did not seem to help he had been on prophylactic
ivermectin for many months just this is actually my husband this patient well
ever that would be a first start I'm gonna have Scott take over here on LDN and
he's on LDN and he was for like four months so red blood cell company is
part of microclotting but there's more to it than that and Scott so if ivermectin
didn't seem to have an appreciable impact what would you think of doing next
what I would say about ivermectin is beyond what Dr. American Pierre said
about ivermectin responders that and this is of where are you Jordan I feel
like I always want to talk to you about this I had a conversation with him but
but in my experience treating hundreds of people for microclotting
maintaining ivermectin on a daily basis helps those patients do better over the
longer term specifically because as Dr. Shine wrote about in the paper that Dr.
Merrick reference that endothelial cells have 28,000 glycan receptors in about
175 ACE2 receptors and red blood cells and platelets have no ACE2 receptors but
ivermectin interferes with spike impact activation of CD147 receptors and
glycan receptors on red blood cells and platelets and endothelial cells so if
we're trying to manage microclotting I think that that is it's very clear in
our patients that when we maintain a baseline of ivermectin they do better
okay a couple of dose are you I think you can spit ball 12 milligrams it's an
easy dose to get from India and I see clinical response there's a couple
interesting points to bring up here one is okay so he's not vaccinated but there
is a dynamic there where he traveled to Florida and he got worse right did he get
on and go to an airport did he get on an airplane yeah was there shedding well it
wasn't it wasn't necessarily that he got worse it's just that he realized that it
wasn't just him being tired it was post tax season okay so I think I think he was
like holy crap like I can't ride my bike on a flat surface at sea level okay I'm
just gonna say there that's the two minute that's a two minute biopsy there
okay he went to an airport he got on a plane yeah now the other thing is he
lives at 5,000 feet and his body has achieved homeostasis to a degree at 5,000
feet and I've seen this in multiple patients that are in Utah or Nevada or
Colorado and when they go down to sea level there's trouble like it's it's not
I mean he has he has hemoconcentration because his body's adapted to living at
higher altitude and then he goes down to lower altitude well actually I don't
agree so people at elevation generally don't have I want to say polycythia but
very high hemoglobin okay that high is was normal diagnostic of the gas of a
new gas exchange deficit that's not from living in elevation the theory no that
was new he had normal hemoglobin previously he had his replacements my
I deferred to both of you on that and and the point that I'm trying to make is
that when you have someone who lives at altitude do you correct they're in
homeostasis in their pathology and they go to sea level and they're typically
going to become dysregulated and that's actually that's actually when I see
people decompensate and their oxygen and I totally agree I've had the same
experience and I've had it on the actually more of the experience on vice
versa I've had a patient sea level and I have one who lives in Columbia at 9,000
feet and they travel constantly and every time she changes elevation she gets
sick or she gets sick or at sea level and then they'll travel for a while and
then when they go back home she's sick for a couple of weeks on on acclimation
I totally agree with Scott on the homeostasis but interesting you know
here I was thinking that he his body was like he because we didn't think it was
long COVID at first we thought because you know he hadn't really been
complaining at all until partway through this whole series we were thinking oh
yes polycythemia and so the thought was that maybe his body was just like had
been having a trouble for a while and produced more red blood cells so that he
could feel better and carry more oxygen so that was that's what the body's
trying to do but there's a deficit that's triggering because it's getting
stuck but here so I like Scott's point about having ivermectin as a
foundation I don't know what vena pep is a bio it's a bioregulator it's actually
out of Russia it's for endothelial healing it promotes healing so the
peptides are you know bioregulators that do a lot of things like for immune
system and also because it seems to have had some physiological benefit and I'm
wondering what its impacts on clotting it's supposed to help prevent
thrombosis and yeah I my sense is that the benefits are somehow addressing the
micro clotting in the micro thrombosis yeah I mean I would be talking well
first of all I would want to do a micro clotting test yeah we don't have a
spike antibody test and I would be I would be talking to him about accelerating
the therapy right trying trying brain fart Plavix and trying all the class so
on a note on that we talked about triple therapy previously the patient did
suffer with pretty significant nosebleeds we we read dinner he was in the
restroom for two hours with a serious nosebleed because he's on is on oxygen
at night still but was on fair amount of oxygen and the natto lumbar o seropetase
and aspirin here's one of the things I would say about that you know we around
Plavix we've kind of been handed this idea that well Plavix is a 75 milligram
DLE dose black and white right but in my experience I have a patient who
couldn't walk a hundred feet from her barn to her house and in two years
dozens of doctors 50 different therapies didn't see a shift she started
Plavix one-quarter tablet twice a week and she went on a 12 mile hike so what
was the increased risk of bleeding from a quarter tablet of Plavix so would you
stop the others the natto seropetase there's those and just add there's
essentially no increased risk of bleeding from taking natto kinase right
right and we I don't know if it was just the oxygen but it was yeah I wouldn't
severe I wouldn't stop this okay okay we routinely will do triple full dose
plavix that was my first thought I was gonna say with any sort of bleeding sort
of issues like nosebleed I have had a patient who's here actually who shaving
cut you know couldn't get it stopped for a long time but you decrease the Plavix
and you actually still retain clinical benefit you commit and especially some
patients don't complain a lot of bruising on Plavix and just reduce the
dose or sometimes we even remove Plavix and we'll use alternative and by the
way the arc micro tech in patients that are on anticoagulation therapy it
almost completely eliminates issues of bruising and bleeding well the micro
current device that we spoke of right yeah I would definitely pursue and I
we call it triple but we actually always keep natto I don't know if I would
call that quadruple but we routinely do triple therapy in the presence of a
significant matter significant matter for everyone and like Jordan had
recommended he was gonna try to connect us with like Jardience another Jardience
with the endothelial one inhibitors yeah if he's been worked up for that yeah
you can try the natto kinases one but I'm glad he's having some improvement I'm
kind of intrigued by this yeah this peptide that he's peptide it's pretty
amazing some some mechanism which seems to be hitting you know what what's
right in the last week actually so yeah I think more of a focus on micro
clotting and and you know let us know how he does okay thanks so much oh by the
way you didn't come sorry you didn't introduce yourself when you came up you
wanted to tell the crowd who you are who I am oh I'm sorry I'm Karen Karen
Minchow I'm from Salt Lake City Utah all right thanks okay good morning can you
hear me I'm Jane Donaghan I'm a nurse I've been a nurse for 30 years but I'm
not really here as a nurse I'm here as a mom and a friend the case that I'm
presenting is one of my best friend's daughter she's 12 years old it actually
just started the beginning of this October and as of last night my friend
sent me a text and said she's actually getting worse almost now seems like
PAN's PAN does symptoms too but I'll go into that afterwards so initially
oh wait here we go initially she was having she was exposed to COVID and had
like a viral illness in September of 23 a few weeks later in the beginning of
October 23 started having tons of GI symptoms nausea no vomiting diarrhea
abdominal pain also was complaining of very dizzy the room spinning my friend
brought her doctor to the primary care multiple times and they kept just
sending her home saying they thinks it's just anxiety and they were kind of
blowing her off so basically here's her history here 12-year-old female she was
in good health until September of 23 she developed the viral flu like illness
which my friend ended up telling me it was COVID following that abdominal
pain like I was saying nausea it was actually no vomiting diarrhea intermittent
fevers and dizziness vibrant kid full of energy her smile lights up the whole room
I've always said to her since she was probably said she could talk that she
was gonna be the president here someday in America so prior to developing this
like happy-go-lucky not a care in the world I'm just really desperate to help
her get back to her old healthy happy self so I put the timeline here basically
they did start checking stuff after her mom kept bringing her to the doctors she
did have some elevated liver enzymes continued with the nausea and diarrhea
felt like the room was spinning they thought it was the benign positional
vertigo they did an Epley maneuver and it didn't have any effect again in
November another fever nausea abdominal pain diarrhea they tested her for
strepe it was negative she was referred to a GI specialist and the plan was to
repeat the liver enzymes in four weeks if they didn't go down and refer to
hepatology in December same thing another fever sore throat body aches
nausea right lower quadrant tenderness they tested her for COVID strepe flu A
and B Epstein bar and they all came back negative they did do a stool test for
inflammation and it was lactoferrin and Calprotectin those were both elevated so
then they sent her to have a colonoscopy she was diagnosed with lymphocytic
colitis started on sulfazalazine and prednisolone and neither one of those had
any effect on her she started to develop anxiety and was waking up with
panic attacks and just kept getting worse nausea and dizziness the neuro
consult was done basically they did a brain MRI because they wanted to rule out
venous sinus thrombosis that was ruled out they also have she's supposed to
have a cardiology referral but she hasn't seen them yet they tested her
feline disease said it was negative when she went on January 18th to her GI
appointment started on her cyber heptadine buidesanide and the plan to was to
repeat the fecal Calprotectin her fecal enzyme were normal now there's no
inflammation there on a stool just as of last week and then they did do a PT
console because she's very deconditioned and they were questioning the same the
benign vertigo I already told you just all what the testing was done there and
then so for medicines anti-imetic on Danza Tron didn't really do much but she
was still taking it land Zopras all corticosteroids prednisolone buidesanide
the sulfazalazine they did put her on the anti histamine cypro heptadine and
none of those had any results symptoms everything's been unchanged some
abdominal have symptoms have just improved over time but not fully resolved
dizziness is unchanged she's complaining it's so bad feels like the room is
spinning all the time I already told you this the Calprotectin and Laro fact
lactoferrin are back to normal and she's supposed to have a cardiology consult
and an allergy consult so I just want to just quickly read this message that I
texted my friend last night her mom just to say like what is the current update
so I could be up to date today so she wrote back to me this is basically just
like a brief synopsis we first brought her to the doctors in October for a
possible strep test because she had swollen glands in her neck also had
stomach pain her friend had COVID a few days before and then Devin came down
with symptoms I did a home test it was positive strep test came back negative
but the medical assistant excuse me half asked the test because the child was
fighting with her center to the GI specialist long story short after GI at
that point which was I believe November this is when she started to become very
isolated non communicative non-verbal could not get out of bed couldn't go to
school had that glaze look in her eyes she said she didn't feel alive she feels
like a zombie she would have outburst but it would more be like panic attacks
and it's it feels like she changed overnight she hated taking her medicine
wouldn't eat certain things that she associated with the medicine like the
bone broth she wouldn't use an orange straw because her medicine was orange so
that's kind of where it is today so I came here in hopes that you guys can
help her it's awful to see her going through it my son had a COVID thing
that he went through in 2021 and but now he's a freshman in college so I'm
happy about that but I went through a lot of these same things where the
doctors were blowing us off my son ended up having Iliadis from COVID and
nobody would see him basically over a period of nine months and I finally
brought him to Boston Children's and I was ready to call the media and you know
just throw a fit until somebody did something so when they brought him in I
knew it was from I'm like he had COVID and he's never been right since there's
something going on with his GI system he had malnutrition they had to put a do
an NG feeding tube and they were afraid of refeeding syndrome with him long
story short of that that's a whole nother story but I'm glad he's doing
better they basically at first tried to diagnose him with an eating disorder so
it was it was a tough go but I know what my friend's going through so that's why
I'm here today so I just this is her doing this amazing slit and I want to
get her back to where she was yeah let me start with a question do you know what
dose of pridinazolone or bedecinide and it was the bedecinide nebulized or
inhaled the bedecinide is pills it was pills I think I have it here I just she
printed off all of her records for me but the pridinazolone was back in I
think October and I believe she's on the bedecinide now but I'm not positive of
the dose off hands yeah and the pridinazolone I presume was for a
discrete course it was not a chronic medicine it was just yeah just for the
GI when they found the colitis yeah I mean clear so she's not so most of her
current issues are gastrointestinal which seems to be somewhat resolving but
mostly neuropsychiatric right so she is at times withdrawn she has fits she's
now getting picky with her foods and she has odd associations with colors that
she doesn't like and it which is exactly typical new behavior for her she's
never been like that never been like that was normal typical healthy 12 year
old and I mean you said in your introduction that you were worried
about pans pan is and that has been described with COVID you know the first
illness it was a flu like illness not no testing for COVID presumably it was
COVID in September of 2023 she had a later one which there she was negative
for everything including COVID correct second yes and she may or may not have
gotten worse after that second bout it seems like she did get worse yeah and
she can't go to school anymore she's basically what she's been doing now is
going to school for two hours a day and most of it is they're trying to just like
get her out of the house but she's mostly spending it in either the nurses
office or the like the school counselor's office does she have separation anxiety
like from her mom like if she has to go to school I didn't ask her that I mean
yes she doesn't want to go to school but I didn't ask her specifically about
separation anxiety we have someone behind you who might have a few words to
share so I can't help myself because this kid really needs help and yes she
does ideas so first of all just because she had two negative strep tests I don't
think that anybody's ruled out pandas much less pans so I would suggest that
you get ASO and anti-DNAs titers which is a blood test should be easy to do at
her age and if money is no object I would also do a Cunningham panel because
that will give you a lot of auto antibodies including things like
auto antibodies to dopamine which if she has that she's not going to be able to
you know really pay attention in school anyway the other thing I would recommend
is the organic acid test from one of the functional labs like Genova or Great
Plains that's going to give you your mitochondrial markers you can look at
the alanine to lysine ratio which is a subtle sign of mito disorder if you
don't have your mitochondria working your brain can't work so one of the things
I would do for her therapeutically and I think you could even do this
empirically would be to give her some mitochondrial support like L-carnitine
CoQ-10 make sure she's taking a multivitamin that has riboflavin niacin
and vitamin C in it and might even do some high dose vitamin C because that's
good for whatever ales you the other thing I would do is I'm sure hopefully
somebody along the way did orthostatic blood pressures to see if she has this
syndrome called POTS where she would need to have lots of water a day like 60 to
100 ounces which almost nobody ever does salt and possibly fluid or cortisone
also I would I would treat her as if she has brain inflammation and one good
product is NeuroProtect that was made in conjunction with Theo Theoridity so I
always butcher his name but I love him he's a wonderful immunologist very well
published in the classic literature it's got Ludiolan and Rootin in it so
that's very good and then I would do quercidin as a mass cell stabilizer
because that kind of gets those mother cells for all kinds of inflammatory
markers something simple like a mega three essential fatty acids I would push
the doses at least a three to five grams a day when you look at the
combination of EPA and DHA and you know the gut brain connection you know right
now her Calprotectin and Lactoferin are better but that doesn't mean she's got
good gut flora so I would have her on a good probiotic I would look for the
possibilities that there are foods that are exacerbating her illness because we
have seen kids that if you take away gluten for example their neuro status
improves remember celiac disease is the abdominal version but you can
also get the brain version for that and I wrote down a mantidine because it's
good for OCD type behaviors at some point you said something that made me
think about that but then yeah I lost my train of thought I think there was a
sound of like some OCD and sometimes you don't know what's going on in the
child's brain they don't share those things with you right many cases of
children who are racked with actually very disturbing recurring thoughts and
they keep them to themselves and especially the pickiness around the
straw it makes me think of OCD because that's what they start to do they
restrict food there's a lot of germ thoughts that the fears of germs so it's
clearly pan I think Elizabeth right this this really sounds like panspan is
physiology and I like all of Liz yeah I'm like crude I'm a critical care doctor I
am really suspicious that she hasn't gotten a full steroid challenge I
actually think I'd like to know what those doses and durations were and at
some point I think she needs to be really challenged with a good corticosteroid
treatment to see the response and also remember about zinc for her gut because
she at least at one point had a high lactoferrin and cow protectant so we
know her gut was inflamed so her cells are not going to be nice tight junctions
and zinc is one of the things that helps you repair those junctions you could
look at a zonulin on her to see if that's abnormal but I would give zinc anyway
because you need zinc to think and it's I would I would look at a very
multimodal but perhaps more simple functional and not so much one
prescription to the next and thank you guys for letting me jump in thank you
and the last thing hey Dr. Mampa maybe you could write these down for for
James so she can thank you thank you so much okay thank you brilliant fall
lastly probably the greatest the goal that my other organizations had you know
neuroimmune.org has been trying to educate and develop a director of
providers and we've been doing this for years and I will tell you the saddest
thing is we have not succeeded there's literally a handful of providers around
the country that are known for truly specializing in panspanas and a couple
of them are I think overcharge and actually prey on patients and so it's a
pretty bleak landscape however I just met someone a week ago who I was very
very impressed with does tell a health and I'd like to make that referral great
yeah see a specialist who can focus and this particular doctor has explored
many other different therapies than just steroids and I think I think we
worthwhile to consult them. Okay great thank you very much thank you everyone okay
thanks guys
okay it's my pleasure and honor to introduce our next speaker who's a
friend and colleague of mine James Lyons-Waller I call him Jack right Jack
and he's the founder and CEO of the Institute for Pure and Applied Knowledge
which conducts biomedical research in the public interest without profit
motive and he runs IPAC EDU an organization that I still owe a lecture
to an online institution of advanced learning in 2019 he founded and is
editor-in-chief of the journal Science Public Health Policy and the Law a place
we can all count on to provide objective and thorough peer review for our case
studies case series and randomized trials that journal has been responsible
for several important truly scientific publications in COVID and I'm honored to
have him here and thanks for joining us Jack and tell us about the Pure you're
building for science. Thank you so much so I have a box of cards here too I've
given the Pepe but I think he's going to throw them out I mean Dr. Corey sorry so
you know I have a lot of slides to share with you one of which I left out due to
time constraints is Dr. Corey breaking into a pharmacy to steal ivermectin for
his patients but that's okay because I can't show it to you because if I do
he'll show you the one of me breaking into the pharmacy to break all the
vaccine vials in half and stomp them but listen you know where did science go
wrong science go went wrong when people learned that they could game the system
for profit that's about the same time that medicine went for profit now
profitable medicine is a necessary and good thing we live in a capitalist
society and we don't want people telling us what to do but nevertheless at the
basis and at the core and in the heart of academic medicine is academia and
academia requires academic integrity my bio I don't have time to go in deep on
it but I was in the Department of Pathology at the University of Pittsburgh
for a good number of years Department of Biomedical Informatics and I was
housed in the University of Pittsburgh Cancer Institute in the first three
years when I served there I brought in twenty seven and a half million dollars
collaborative funding for cancer research because mom died from breast
cancer when I was four years old and every patient and every data set that I
saw was somebody's mom dad uncle brother sister so individualized medicine was
natural to my heart and I'm really sad that they didn't continue along that
line but academic integrity requires that we do not lie do not cheat do not
steal do not fund execute and mess up deadly gain of function research that's
all it takes just you hear CDC say things like oh my gosh we lost the game we
don't have public trust did you know 35% of American citizens trust allopathic
medicine check it out Rasmussen poll what's 100 minus 35 anybody good at math
okay that's a huge percentage of people that no longer trust allopathic
medicine game over we win we win it's a landslide okay so but nevertheless we
do have to talk with each other about how we act behave and what's normal and
acceptable and in society I'm thinking about about George Costanza right now
from Seinfeld we live in a society you know but focus on reality if you're
going to have any kind of public health at all that matters you have to focus on
reality not messaging and if you're going to have public health at all don't try
to earn back trust act trustworthy act trustworthy and I was at an estate sale
with Gracie who I owe so much to she's gone through so much to make sure that
we can do what we do and I saw this little sign on the estate sale in the
basement of this guy's shop and it says do not only do things right do the right
things right so we also should respect the law and policy but I'm as
anti-establishmentarian whatever they call it authoritarian as they come and
it's a good thing too because I don't take this garbage but understand and I
learned this from David Brownstein and from Paul Thomas that the standard of
care has been co-opted by a centralized authority when the standard of care
really should be grassroots bottom-up what you guys are doing right now hey
what did you see with this patient did it work I'm in I'm in the county next to
you I'm calling you up I have this do you are you seeing it what's working the
standard of care comes because that's how an intelligent system works an
intelligent system has its feelers out and it's taking information in and
consolidating it up not Fauci telling you don't do medicine for 10 days and then
see what happens after people get as sick as possible with room with RSV with
influenza with bacterial pneumonia after they come to the emergency room
after getting home going home for 10 days without any medical care I could go
on about that almost everybody who died on ventilators had bacterial pneumonia
and we know where they got it they got it at home severe bacterial pneumonia
listening to Dr. Fauci and his medical advice I mean that so I have to go back
how do I go back on this okay so so how do you how do you have respect for law
and policy when it's when centralized way we all know is wrong we don't all
have time to check with everybody else in a highly parallel way well we kind of
don't but we can share information online we can share information very
quickly through modern publishing means but understand the basis of sovereignty
comes from the individual not the state sovereignty comes from the individual a
state is a collection of individuals everything about a state comes from the
collection of individuals therefore respect individual rights because
without individual rights you don't have a state and if there's a crisis ask do
not demand personal sacrifice then you can get a buy-in from people on the
basis of their own perception of risk and balance and what they're doing for
society I founded research so that independent research in the public
interest could survive but this was well before COVID I did it in 2015 I could
see the writing on the wall after writing a chapter on vaccines and I found
that study after study after study after study was fraudulent when I was at
the University of Pittsburgh I created a research core called the bioinformatics
core and me and my staff designed and executed and I directed the analysis of
over a hundred research studies from all different departments and you know all
politics is local in all the departments there's territorial disputes and
everything else I didn't gossip I kept it all in a silo but the weird why am I
telling you that well I only saw two cases of potential fraud while I was at
the University of Pittsburgh and I thwarted both of them two out of a
hundred studies that we did but it was more like 300 meetings that I had with
people because they all didn't come to fruition so academic fraud is not as
widespread as in the academic the major medical systems as it is at the CDC the
fact that they turn a blind eye to CDC's fraud that's incriminating but you
have to let the data speak and and you should publish what you find not what
you want to find there's so much in that thank you so if you go to IPA
knowledge or you can support our minor research endeavors such as determining
the first ever pediatric dose limit for aluminum and in pediatric vaccines and
then determining that all children on that CDC schedule are in a whole body
aluminum toxicity 100% of their days of life CDC didn't do that that was IPAC
determining that in the first day of life in a hepatitis B vaccine that kids
are getting 16 times the body mass adjusted dose that an adult safe
safe level is for for 850 micrograms for adults so on and on we also created
IPAC EDU where we have 40 courses and 30 instructors and I'm just going to say
that the doctors that take the courses one of them told me called me up and
said I signed up for your immunology course Dr. Jack in the first lecture I
learned more about immunology than in that one lecture that I did in all four
years of undergraduate school and in medical school the curriculum tracks are
broad and deep broad and deep if you don't like I mean we don't offer CMEs
of that kind of thing yet but our courses can be licensed by organizations
that do and I want to partner with your organization if they do we can very
easily license your use of our lectures so easy science public health policy and
along this is the most exciting thing I can tell you today the most exciting
development is this open access international cope compliant peer
review journal we've had as as Pierre said a few impacts during COVID there's a
massive overhaul coming but we publish things like PCR tests actually don't
work Dr. Singh hang Lee why because they don't have a negative control and you're
just guessing or picking out of the air a CT value cycle threshold value so you
should do Sanger sequencing to confirm the virus is there okay Dr. Singh hang
Lee did this it comes with editorials saying stop stop that okay we publish
this Mary Hollins here we publish this significant underreporting of HPV
vaccine associated serious adverse events they went and asked medical
doctors to go and look at the the submitted information in the records at
VAERS and they found that they're misclassifying many many clinical
conditions following HPV vaccine that's intentional Dr. Jessica Rose you ever
hear about her yeah exactly so she wrote she wrote two papers and published them
in our journal one of them was based on a tweet that I made where I showed that
after the first after the vaccine after COVID vaccines almost all the deaths and
adverse events were happening the first and second day after the vaccine which is
statistically improbable if it's there's no association it should be day one two
three four five six seven is equal she published this in our journal and it's
very very strong argument to say that there's a there's a temporal causality
so we're you know partway there this is don't have time to go into details but
it's a data data point after data point she was an IPAC research fellow when she
was doing that research Dr. David Brownstein was under threat of destruction
of his practice by the FTC don't ask me how the FTC is going to destroy these
things just reach look at the letters that your colleagues were getting from
FTC for practicing medicine and he said well they're going to shut me down I
said well how many have you treated with your protocol he said a hundred and I
think a hundred two hundred seven and I said how many died he said none I said
that's a lot less than what we're seeing elsewhere why don't you publish a case
series he published it the FTC packed their bags and went home so did Dr. David
Brownstein so this year we're taking back science this year is the end of 1984
you know what I'm talking about once we take back science we can then take back
medicine writ large I believe in a no prisoners policy I don't want to give
pharma another single inch of American territory another inch of economic
territory another inch of our psyche our psyche none zero and they we have to put
them in retreat and the way that we do that is by doing what they can't do we
do objective science period it's so simple so this journal will publish via
letters to the editor correspondence core agenda etc randomized peer clinical
trials systematic reviews meta-analysis all the standard conduits for
transmitting information through objective peer review Dr. Peter McCullough
has just joined the journal as the clinical section editor-in-chief we will
never spitefully or in any way target a paper by weaponizing with tracks by
weaponizing retraction instead we will do the civilized thing if there's a
problem with the paper we'll invite the authors to address the problem with
erratic or agenda and so on objective rational discourse debates it with
letters to the editor hello let's hear both sides and let the community decide
but if there's a serious problem we'll let them fall on their own sword and
withdraw this paper was targeted by the supervisors in the institutions of the
authors of this important study for retraction and when I did the right thing
and acted like an academic scholar and a gentleman and I said well you know guys
if you see if you see there's a problem you have the right to withdraw I was
contacted by the people that were harassing them and they threw a hissy fit
and cried and pitched a fit about how no no no you have to with you have to
retract it why because that's a penalty a withdrawal is never happened I pull it
back it's so much more civilized and so much better so we have four sections
now we're adding a fifth section each of these sections is like its own
independent journal with a section editor-in-chief science it's everything
we can publish anything public health policy oh yeah we've got your number now
law you know we need people Aaron Siri and so on our heroes are just doing so
much work they don't have time to write down exactly what they're doing but we
need other people that are smart in the areas of the law to actually analyze
what's happening and interpret what's happening and through like you know case
environmental pace environmental law review where Mary Holland's paper one of
the most important papers on the issue of vaccine safety ever was published we
need considered analyses that are academic with and not making that a
gold a gold ring that nobody could ever reach except for the people that want
to game the system and in court it's really important and on the and the
other one is mind science clinical research in mind science so these are
sections whole sections I'm giving you the first ever peek at what the new
revised journal is going to look like all of this content most of this content
is made up okay it's just filler this is really a mock-up okay but you can one
of the papers autism tsunami is real we published that after peer review but
look at this beautiful thing we have news items we have editorials you can read
McCullough Foundation support we also have massive support from the West
Reich Foundation to make this happen for you guys this is going to be the
premier information resource for not just our community but for the society at
large that's interested in objective science we're taking no prisoners the
news items are not going to be pulled from headlines that are bought AI made
that cover so it's misspelled but see we're it's just going to be beautiful
and this is coming out probably in a month or two clinical research section
will have its own section the law section will have its own section oh here's a
paper that we'll never publish probably advancement in vaccine technology
paving the way for next generation of museums that my what this is a troll by
my web developer okay thank you funny guy it's an AI generated article it's
really good read it but and then another exciting thing is tomorrow we'll be
registering with the HHS that we're forming a 35-person IRB and institutional
review board to be able to review to review studies that are human subjects
research studies that no IRB in the planet will otherwise give waivers to
or overview so I sent out 50 invitations we got 50 yeses 35 have trained we're
going to register this week that's huge that's going to be something that you
could just go if you have want to do a case series and write it up and you're
afraid that you're going to get charged with not doing an IRB if you have a
data request in California that you want another vaccination status you can get
at your IRB you don't have to rely on theirs so this is coming too how did I
do this ten years of sustained effort I started in this fight 2014 and I've been
at it every day most days 16 days a week 16 days most days 16 hours a day it's a
lot to do but I can see the future and the future is bright because we're
winning go to ipak-edu.org and just thank you for all that you're doing for
all of your patients that little pit feeling that you have that maybe you
didn't get it right first time move on let's do it
all right we are going to be taking what an amazing thing an IRB at our
disposal and I love this idea taking science back but we got to get the
science back just what an incredible concept so this is the kind of progress
and movement we're talking about
